2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-10935
    LY450108 376594-67-1 99.51%
    LY450108 is a potent AMPA receptor potentiator. LY450108 has the potential for depression and Parkinson's disease research.
    LY450108
  • HY-12149
    A-867744 1000279-69-5 99.76%
    A-867744 is a highly potent and selective type II positive allosteric modulator (PAM) of the alpha7 nicotinic acetylcholine receptors (nAChR) with an EC50 of 1.0 μM.
    A-867744
  • HY-15476
    VU 0364439 1246086-78-1 99.42%
    VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.
    VU 0364439
  • HY-17554
    (R)-Oxiracetam 68252-28-8 99.94%
    (R)-Oxiracetam is the (R)-enantiomer of the nootropic drug oxiracetam.
    (R)-Oxiracetam
  • HY-50865
    PDE-9 inhibitor 1082743-70-1 99.79%
    PDE-9 inhibitor is useful for neurodegenerative diseases.
    PDE-9 inhibitor
  • HY-B0916
    Propoxur 114-26-1 99.43%
    Propoxur is a reversible, competitive, orally active AChE inhibitor that can cross the blood-brain barrier. Propoxur inhibits AChE activity to induce neurotoxicity, while promoting MMP-2 expression and enhancing tumor cell migration and invasion by inducing intracellular ROS generation and activating the ERK/Nrf2 signaling pathway. On the one hand, Propoxur inhibits AChE, leading to acetylcholine accumulation and causing neurological dysfunction; on the other hand, it promotes Nrf2 nuclear translocation through ROS-dependent ERK1/2 phosphorylation, and upregulates MMP-2 and other invasion-related proteins. Propoxur is also a carbamate insecticide used to combat turf, forestry, and household pests.
    Propoxur
  • HY-B1319
    Pramocaine hydrochloride 637-58-1 99.74%
    Pramocaine hydrochloride decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses.
    Pramocaine hydrochloride
  • HY-D2268
    QM-FN-SO3 2316820-94-5
    QM-FN-SO3 is a BBB-penetrable near-infrared (NIR) aggregation-induced emission (AIE)-active probe for Aβ plaques. QM-FN-SO3 can be used for in vivo detection of Aβ plaques. QM-FN-SO3 has ultra-high S/N ratio, binding affinity, and high-performance NIR emission.
    QM-FN-SO3
  • HY-I0230
    Solifenacin hydrochloride 180468-39-7 99.71%
    Solifenacin hydrochloride (YM905 hydrochloride) is a muscarinic receptor antagonist, with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively.
    Solifenacin hydrochloride
  • HY-N1179
    Tanshinone IIB 17397-93-2 ≥99.0%
    Tanshinone IIB is a major active constituent of the roots of Salvia miltiorrhiza (Danshen) widely used for the research of stroke and coronary heart disease in Asian countries. Tanshinone IIB has a neuroprotective effect via inhibition of apoptosis.
    Tanshinone IIB
  • HY-N1713
    29-Nor-20-oxolupeol 19891-85-1 99.84%
    29-Nor-20-oxolupeol, extracted from Impatiens basamina, reduces NO levels in LPS-activated murine microglial cells with an IC50 of 44.21 µM.
    29-Nor-20-oxolupeol
  • HY-N5086
    Picroside IV 211567-04-3 ≥99.0%
    Picroside IV is an iridoid glycoside found in the underground parts of Picrorhiza scrophulariiflora. Picroside IV is a derivative of Catalpol (HY-N0820). Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects.
    Picroside IV
  • HY-N9125
    Adoxosidic acid 84375-46-2 ≥98.0%
    Adoxosidic acid is a SERT enhancer can be extracted from N. jatamansi and can be used in antidepressant research.
    Adoxosidic acid
  • HY-100649
    Hydroxy ziprasidone 884305-08-2 99.53%
    Hydroxy ziprasidone is an impurity of Ziprasidone. Ziprasidone, an antipsychotic agent, is a combined 5-HT (serotonin) and dopamine receptor antagonist.
    Hydroxy ziprasidone
  • HY-101695
    EP1-antagonist-1 851204-35-8 98.60%
    EP1-antagonist-1 is a EP1 antagonist with a pKi of 7.54 and an pIC50 of 8.5.
    EP1-antagonist-1
  • HY-111812
    Tricin 7-O-glucuronide 32769-02-1 99.09%
    Tricin 7-O-glucuronide is an Alfalfa (Medicago sativa L.) flavonoid.
    Tricin 7-O-glucuronide
  • HY-116302
    MMP-9-IN-9 206549-55-5
    MMP-9-IN-9 (compound 4f) is a slective MMP-9 inhibitor with an IC50 of 5 nM. MMP-9-IN-9 shows selective for MMP-9 over MMP-1 and MMP-13. MMP-9-IN-9 shows strong anti-inflammatory and neuroprotective effects.
    MMP-9-IN-9
  • HY-123800
    BI 187004 1303515-32-3 98.13%
    BI 187004 (VTP-34072) is an 11β-hydroxysteroid dehydrogenase 1 inhibitor for use in diabetes research.
    BI 187004
  • HY-124001
    N-Docosanoyl taurine 783284-48-0 ≥99.0%
    N-Docosanoyl taurine is a lipoamino acid. N-Docosanoyl taurine is a discriminatory metabolity that drive the classification of brain regions.
    N-Docosanoyl taurine
  • HY-124462
    Trifluperidol hydrochloride 2062-77-3 99.4%
    Trifluperidol hydrochloride is a Sigma-1 receptor antagonist with a Ki value of 3.3 nM. Trifluperidol hydrochloride is used in the study of psychosis.
    Trifluperidol hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity